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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Micaela Mitolo1,2, Davide Braghittoni3, Greta Venturi3

  • 1University of Parma, Parma, Italy, Italy.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Dementia with Lewy Bodies patients show attentional deficits and poorer performance on sustained attention tasks. Reduced brain activity in the cuneus and precuneus is linked to slower reaction times in DLB patients.

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Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Dementia with Lewy Bodies (DLB) is characterized by attentional deficits.
  • Understanding functional brain activity during attention tasks is crucial for DLB research.

Purpose of the Study:

  • To compare functional brain activity during a sustained attention task between DLB patients and healthy controls.
  • To identify specific brain regions and networks affected in DLB during attention tasks.

Main Methods:

  • fMRI study involving 20 DLB patients and 20 healthy controls (HC).
  • Auditory Psychomotor Vigilance Task (PVT) used to assess sustained attention.
  • Neuropsychological assessments and brain MRI with fMRI data analysis.

Main Results:

  • DLB patients exhibited poorer performance on visuospatial and sustained attention tests (PVT).
  • Significantly reduced brain activation in DLB patients compared to HC in the right superior lateral occipital cortex, cuneus, and precuneus during the PVT.
  • Slower reaction times in DLB were correlated with decreased activation in the cuneus and precuneus.

Conclusions:

  • DLB patients demonstrate impairments in attention and visuospatial domains.
  • The cuneus and precuneus play a critical role in sustained attention, with reduced activity linked to cognitive deficits in DLB.
  • Further research with larger DLB cohorts is necessary to elucidate the functional mechanisms of attention deficits.