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Clinical Manifestations.

Shalom K Henderson1, Ajay D Halai1, Kamen A Tsvetanov2

  • 1University of Cambridge, Cambridge, United Kingdom.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Logopenic variant primary progressive aphasia (lvPPA) patients do not have a core phonological deficit. Instead, their repetition difficulties stem from working memory impairments, exacerbated by hearing loss.

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Area of Science:

  • Neurolinguistics
  • Cognitive Neuroscience
  • Speech and Language Pathology

Background:

  • Logopenic variant primary progressive aphasia (lvPPA) is characterized by impaired phonological short-term memory.
  • The presence of a core phonological processing deficit in lvPPA remains unclear.
  • This study investigates phonological processing, working memory, and their neural correlates in lvPPA.

Purpose of the Study:

  • To determine if lvPPA involves a core phonological impairment beyond short-term memory deficits.
  • To assess if working memory, confrontation naming, and phonological performance reflect underlying deficits.
  • To explore the relationship between repetition performance and structural/functional brain differences.

Main Methods:

  • Compared word/non-word repetition and short-term memory in patients with typical Alzheimer's disease (tAD), lvPPA, and advanced lvPPA (lvPPA+).
  • Utilized Bayesian analyses to evaluate group differences and correlations.
  • Examined structural (grey matter) and functional (connectivity) neuroimaging data.

Main Results:

  • No significant group differences were found in phonological tasks (word/non-word repetition).
  • Self-reported hearing loss strongly impacted word and non-word repetition, but not multi-syllabic repetition.
  • Phonological tasks, working memory, and confrontation naming showed no significant correlations, suggesting distinct underlying mechanisms.

Conclusions:

  • Deficits in pure phonological tasks are not dependent on working memory and are influenced by hearing loss in lvPPA and tAD.
  • lvPPA is characterized by a working memory/buffering impairment, not a core phonological deficit.
  • Repetition performance is linked to working memory capacity and potentially influenced by hearing acuity.