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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

Biomarkers.

Mary K Kramer¹, Nicholas J Pyontek¹, Nicholas A Rizzi¹

¹University of Delaware, Newark, DE, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 25, 2025

Summary

This summary is machine-generated.

Magnetic Resonance Elastography (MRE) reveals reduced brain stiffness correlating with Alzheimer's disease (AD) biomarkers in asymptomatic individuals. This suggests MRE can detect early AD-related mechanical changes using accessible blood tests.

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Area of Science:

Neuroscience
Biomarker Discovery
Medical Imaging

Background:

Alzheimer's Disease (AD) pathology, including amyloid and tau accumulation, can be present in asymptomatic individuals, representing a critical window for intervention.
Magnetic Resonance Elastography (MRE) quantifies brain tissue stiffness, offering a method to detect early microstructural changes associated with AD.
The hippocampus and entorhinal cortex (ERC) are key regions affected early in AD pathology.

Purpose of the Study:

To investigate the relationship between brain mechanical properties measured by MRE and plasma-based Alzheimer's Disease (AD) biomarkers.
To determine if MRE can detect early microstructural changes in the hippocampus and ERC in individuals with elevated AD risk.

Main Methods:

Twelve participants from the Delaware Longitudinal Study for Alzheimer's Prevention underwent neuropsychological testing, bloodwork, and MRE.
Plasma amyloid-beta (Aβ) and phosphorylated tau (pTau-181, pTau-217) were quantified using Single Molecule Array (Simoa) assays.
MRE measured the stiffness of the hippocampus and entorhinal cortex (ERC).

Main Results:

Hippocampal stiffness inversely correlated with plasma pTau-181 and Aβ40 levels.
ERC stiffness showed a similar inverse correlation with pTau-181 and a near-significant correlation with pTau-217.
Individuals with lower AD biomarker concentrations exhibited higher stiffness in the hippocampus and ERC, indicating a link between biomarker levels and brain tissue degradation.

Conclusions:

This study is the first to link brain mechanical properties measured by MRE with plasma-based AD biomarkers.
Reduced stiffness in the hippocampus and ERC suggests microstructural disruption due to protein accumulation.
MRE measures show sensitivity to the impact of protein aggregates on brain mechanics, supporting its use in early AD detection alongside accessible blood biomarkers.