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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

Biomarkers.

Fatemeh Tabassi Mofrad¹, John Gallacher²

¹University of Oxford, Oxford, United Kingdom.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 25, 2025

Summary

This summary is machine-generated.

Brain aging involves both grey matter shrinkage and volume increases in specific subcortical areas like the Caudate and Pallidum, suggesting inflammation may play a role in cognitive decline.

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Area of Science:

Neuroimaging
Neuroscience
Aging Research

Background:

Age-related cognitive decline impacts independence and lifespan.
Subcortical brain structures are implicated in cognitive deterioration.
Comprehensive documentation of age-related structural brain changes is needed.

Purpose of the Study:

To map age-related volumetric changes in subcortical grey matter.
To investigate the relationship between age and subcortical brain volumes.

Main Methods:

Utilized T1-weighted structural brain scans from 46,111 healthy individuals.
Divided participants into middle-aged (44-60) and older (61-83) groups.
Employed path analysis to examine age-related subcortical volume changes, with model fit adjustments.

Main Results:

Age positively correlated with increased volumes in the right/left Caudate, Pallidum, and left Putamen.
Age negatively correlated with decreased volumes in the Brain Stem, left Thalamus, right/left Amygdala, and Hippocampus.
Observed differential volumetric changes across subcortical regions in older adults.

Conclusions:

Age-related structural brain changes include both grey matter shrinkage and volume increases in subcortical areas.
Increased volumes in Caudate, Pallidum, and Putamen suggest age-related brain inflammation.
These inflammatory changes may precede neurodegenerative disease pathogenesis.