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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Bardiya Ghaderi Yazdi1, Peter Chernek1, Seyed Hani Hojjati1

  • 1Weill Cornell Medicine, New York City, NY, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Normal aging does not significantly alter brain network stability. Healthy controls showed higher limbic network connectivity than cognitively unimpaired older adults, but this finding was not robust. This suggests age-related changes in functional connectivity may be influenced by motion and atrophy.

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Area of Science:

  • Neuroscience
  • Neuroimaging
  • Aging Research

Background:

  • Within-network functional connectivity (FC) is crucial for understanding brain health and disease.
  • Age-related changes in FC are not well understood, necessitating studies in healthy young and old adults.
  • This research investigates alterations in large-scale brain network connectivity with aging.

Purpose of the Study:

  • To investigate age-related alterations in brain network connectivity using resting-state functional MRI (rfMRI).
  • To compare FC in young healthy controls (HC) with cognitively unimpaired (CU) older adults.
  • To control for motion and brain atrophy effects on FC.

Main Methods:

  • rfMRI data from 60 HC and 191 CU participants were analyzed.
  • A comprehensive fMRI pipeline was used, including motion correction and spatial normalization.
  • Inter-regional connectivity was computed using Pearson's Correlations within seven large-scale brain networks.

Main Results:

  • No significant differences in overall large-scale network connectivity were found between HC and CU groups.
  • Healthy controls exhibited higher limbic network (LIM) FC (p=0.02) compared to CU individuals, even after controlling for motion.
  • Amyloid status and motion exclusion did not alter the primary findings, though one analysis showed partially significant higher LIM FC in CU (p=0.056).

Conclusions:

  • Normal healthy aging appears to maintain large-scale brain network stability.
  • Observed declines in FC with aging in other studies may be influenced by motion and brain atrophy.
  • Further research is needed to clarify the precise impact of aging on brain connectivity.