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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Pan Sun1, Xin Zhou1,2, Ying Han2,3

  • 1Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Standardizing Centiloid measurements in Chinese Alzheimer's disease (AD) research using multiple β-amyloid (Aβ) PET tracers and pipelines is crucial. This study established reliable Centiloid coefficients, supporting harmonization in AD clinical trials.

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Area of Science:

  • Neuroimaging and Diagnostics
  • Alzheimer's Disease Research
  • Biomarker Standardization

Background:

  • Variability in β-amyloid (Aβ) tracers, processing pipelines, and thresholds for Aβ positron emission tomography (PET) imaging complicates Alzheimer's disease (AD) research.
  • Establishing standardized Centiloid measurements is essential for assessing cortical Aβ plaques, particularly within Chinese AD research and clinical trials.

Purpose of the Study:

  • To standardize the conversion of Aβ PET data to Centiloid units across different processing pipelines and tracers in the Chinese aging population.
  • To evaluate the performance of Centiloids in detecting AD-related pathologies and their association with tau PET, hippocampal volume, and cognition.

Main Methods:

  • Standardized Aβ PET data conversion to Centiloid units using MRI-FreeSurfer, MRI-SPM, and MRI-Free pipelines for four tracers (18F-NAV4694, 18F-Florbetaben, 18F-florbetapir, 18F-flutemetamol).
  • Calculated Centiloids for 18F-florbetapir across four diverse Chinese aging cohorts.
  • Analyzed associations between Centiloids, tau PET, residual hippocampal volume (rHCV), and cognition, comparing Aβ-negative and Aβ-positive groups based on Centiloid thresholds.

Main Results:

  • MRI-FreeSurfer and MRI-SPM pipelines demonstrated the most consistent Centiloid results; the MRI-Free pipeline also provided reliable conversions.
  • Higher Centiloid values correlated with increased tau PET SUVR, decreased rHCV, and cognitive decline.
  • Different Centiloid thresholds significantly impacted the observed effect sizes for tau PET, rHCV, and cognitive scores between Aβ-negative and Aβ-positive groups.

Conclusions:

  • Established standard Centiloid calculation coefficients for multiple Aβ PET tracers within the Chinese aging population across various settings.
  • Findings offer crucial reference and support for harmonizing Aβ Centiloid measurements in AD studies and clinical trials conducted in China.