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Published on: September 20, 2018
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Clinical Manifestations
Abhishek Mensegere Lingegodwa1, Albert Stezin1, Jonas S Sundarakumar1
1Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
Summary
High Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) scores predict increased risk of mild cognitive impairment (MCI) in older Indian adults. Early identification of high-risk individuals is crucial for timely intervention to prevent cognitive decline.
Area of Science:
- Gerontology
- Neurology
- Epidemiology
Background:
- The Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score is a validated tool for dementia risk prediction.
- Midlife cardiovascular risk factors are associated with later-life cognitive decline.
Purpose of the Study:
- To investigate the association between high-risk CAIDE score group membership and the development of mild cognitive impairment (MCI).
- To assess the predictive value of the CAIDE score for MCI development in older Indian adults.
Main Methods:
- Analysis of data from the TATA Longitudinal Study of Aging.
- Categorization of participants into high-risk (>9) and low-risk (≤9) CAIDE score groups.
- Binary logistic regression to determine the odds of developing MCI (CDR=0.5) after one year, with CAIDE score as both a categorical and continuous variable.
Main Results:
- 48 (3.5%) of 939 participants developed MCI within one year.
- High-risk CAIDE group membership significantly increased MCI odds (OR=2.58, p=0.004).
- Each one-point increase in CAIDE score raised MCI odds by 33% (Exp β=1.33, p<0.001).
- High-risk individuals who did not develop MCI performed worse on ACE total scores.
Conclusions:
- Individuals with high CAIDE scores face an elevated risk of developing MCI.
- Findings suggest shared pathophysiological links between cardiovascular disease and cognitive health.
- Emphasizes the need for early detection and intervention for individuals at risk of both cardiovascular disease and cognitive decline.
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