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A gut-to-brain pathway that limits protein intake
1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Abstract:
In this issue of Cell, Jaschke and Luchsinger et al. uncover a gut-to-brain signaling mechanism that dynamically shapes protein intake. During recovery from extreme fasting, ammonia derived from the metabolism of specific dietary amino acids is detected by Trpa1-expressing intestinal epithelial cells, leading to the activation of a protein aversion pathway.
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