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Clinical Manifestations.

Nancy X Chen1, Rachel Peterson2, M Maria Glymour3

  • 1University of California, Davis, Davis, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Social determinants of health, including financial, social, and cultural capital across the lifespan, significantly impact subjective cognitive decline (SCD). Addressing socioeconomic inequities is crucial for mitigating SCD and preventing cognitive impairment.

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Area of Science:

  • Gerontology
  • Public Health
  • Cognitive Science

Background:

  • Social determinants of health (SDOH) are conditions affecting health from birth through aging.
  • Previous research suggests SDOH may influence subjective cognitive decline (SCD), a dementia risk factor.

Purpose of the Study:

  • To examine the association between lifecourse socioeconomic status (SES) and SCD.
  • To investigate how financial, cultural, and social capital across the lifespan relate to cognitive decline.

Main Methods:

  • Utilized two multi-ethnic cohorts of long-term health plan members without prior dementia diagnoses.
  • Constructed lifecourse SES variables measuring financial, cultural, and social domains based on childhood and current ratings.
  • Assessed SCD using the Everyday Cognition (ECog) scale and analyzed associations using multivariable linear regression models.

Main Results:

  • Low childhood and late-life financial capital, social capital, and late-life cultural capital were associated with higher SCD ratings.
  • In combined models, these SES factors remained significantly linked to worse cognitive function (ECog scores).

Conclusions:

  • Financial, social, and cultural capital throughout life critically shape SCD.
  • Findings highlight the need to address socioeconomic disparities in resource access to mitigate SCD and cognitive impairment risk.