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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Wu Jiayi1, Jin-Tai Yu2

  • 1Fudan University, Shanghai, Shanghai, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Higher physical activity and reduced sedentary time protect against neuropsychiatric diseases. Objective measures reveal significant associations with brain function, inflammation, and metabolism, offering new prevention strategies.

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Area of Science:

  • Neuroscience
  • Public Health
  • Exercise Physiology

Background:

  • Physical activity and sedentary behavior are linked to neuropsychiatric diseases.
  • Previous research relied on self-reported data, which can be inconsistent.
  • Objective measurement is crucial for accurate assessment.

Purpose of the Study:

  • To investigate the association between objectively measured physical activity, sedentary behavior, and neuropsychiatric diseases.
  • To explore the underlying biological mechanisms, including brain function and biomarkers.
  • To identify potential targets for risk assessment and prevention strategies.

Main Methods:

  • Large-scale prospective study using accelerometer data from 73,411 participants (2013-2015).
  • Analysis of energy expenditure, time allocation, and associations with neuropsychiatric disease risk.
  • Inclusion of brain imaging, proteomics, metabolic analyses, and structural equation modeling.

Main Results:

  • Moderate to vigorous physical activity energy expenditure showed a strong protective effect (HRs: 0.60-0.86).
  • Increased sedentary time was a significant risk factor (HRs: 1.05-1.54).
  • Associations were found with specific brain regions, ITGAV protein, lipoproteins, and mediating roles of inflammation and metabolism.

Conclusions:

  • Higher physical activity and reduced sedentary behavior mitigate neuropsychiatric disease risk.
  • Mechanisms involve brain function, structure, and peripheral biomarkers, mediated by inflammation and metabolism.
  • Findings support objective measures for risk assessment and intervention development.