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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Debora Afonso Silva Rocha1, Luis E Santos1, Thaís Lopes Pinheiro1

  • 1D'Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Plasma neurofilament light chain (NfL) shows increased levels with aging in Brazilians, correlating with reduced brain volume. Establishing local reference values is crucial for diagnosing neurodegenerative diseases.

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Area of Science:

  • Neuroscience
  • Biomarker Research
  • Aging Studies

Background:

  • Plasma biomarkers are vital for neurodegenerative disease management.
  • Neurofilament light chain (NfL) indicates neuroaxonal damage and brain volume loss.
  • Local reference values for plasma NfL are lacking in Brazil and Latin America.

Purpose of the Study:

  • Establish local reference values for plasma NfL in healthy older Brazilians.
  • Assess plasma biomarkers in normal aging.
  • Investigate correlations between plasma biomarkers and brain structure.

Main Methods:

  • Analyzed data from 77 healthy older Brazilians in a longitudinal dementia study.
  • Utilized structural T1w MRI and FreeSurfer for brain morphology analysis.
  • Measured plasma biomarkers using a SIMOA HD-X instrument.

Main Results:

  • Determined normal plasma NfL values and annual increase rate in aging Brazilians.
  • Found significant correlations between plasma NfL and reduced grey matter, white matter, mean cortical thickness, and hippocampus volume.
  • Observed strong correlations between plasma NfL and aging (Pearson r=0.4993, p<0.001).

Conclusions:

  • Plasma NfL is a promising biomarker for neurodegenerative changes.
  • Plasma NfL levels correlate with aging and reductions in brain volume.
  • Establishing Brazilian reference values is essential for clinical use in diagnosing and monitoring neurodegenerative diseases.