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Drug Development.

Ralph Kern1, Lily Lee1, Robbert Zusterzeel1

  • 1Cognito Therapeutics, Cambridge, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
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Summary
This summary is machine-generated.

This study explores Spectris™, an at-home audiovisual neuromodulation device for Alzheimer's disease. Early results suggest it may offer a safe and effective treatment option for patients.

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Area of Science:

  • Neuromodulation
  • Neurodegenerative Diseases
  • Alzheimer's Disease Therapeutics

Background:

  • Alzheimer's disease (AD) presents a significant unmet medical need.
  • Cognito Therapeutics is developing Spectris™, a non-invasive, at-home audiovisual neuromodulation device for AD.
  • The device aims to modify the biological and clinical progression of mild-to-moderate Alzheimer's disease.

Purpose of the Study:

  • To evaluate the safety and efficacy of Spectris™ in participants with mild-to-moderate Alzheimer's disease.
  • To discuss the potential impact of Spectris™ on patients, families, and the healthcare system.
  • To provide insights into the use of at-home neuromodulation for AD management.

Main Methods:

  • The OVERTURE trial was a randomized controlled trial (RCT) with an open-label extension (OLE).
  • Participants received daily one-hour active or sham treatment for six months.
  • The ongoing HOPE trial is a 12-month RCT with a 12-month OLE evaluating Spectris™ in mild-to-moderate AD.

Main Results:

  • Clinical and MRI biomarker results from the OVERTURE RCT and OLE will be presented.
  • Comparison of OVERTURE and HOPE study designs and baseline characteristics.
  • Key insights from the evaluation of daily, at-home, non-invasive neuromodulation therapy.

Conclusions:

  • Spectris™ shows potential as a safe, effective, and cost-effective treatment for Alzheimer's disease.
  • The device may broaden therapeutic options for individuals with mild-to-moderate AD.
  • At-home neuromodulation offers a convenient approach to managing Alzheimer's disease.