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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

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Published on: January 28, 2014

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Biomarkers.

Hanna Huber1, Wagner Scheeren Brum2, Laia Montoliu-Gaya2

  • 1University of Gothenburg, Gothenburg, Sweden.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Dried plasma spots (DPS) from capillary blood offer a simple, temperature-independent method for Alzheimer's disease (AD) biomarker detection. This approach enhances accessibility for population screening and research, improving AD diagnosis and study inclusivity.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Blood-based biomarkers for Alzheimer's disease (AD) are increasingly valuable clinical tools.
  • Improved accessibility to biomarkers like pTau217 can enhance population screening and research inclusivity.
  • The DROP-AD project developed an alternative blood collection method to overcome traditional challenges.

Purpose of the Study:

  • To assess the feasibility and accuracy of detecting Alzheimer's disease (AD) biomarkers from capillary blood using dried plasma spots (DPS).
  • To evaluate the correlation between capillary DPS biomarkers and traditional venous plasma biomarkers.
  • To determine the diagnostic performance of capillary DPS pTau217 in identifying AD pathology.

Main Methods:

  • Recruited 344 participants across eight centers, collecting paired venous EDTA plasma and capillary finger-stick-derived DPS.
  • Shipped capillary samples without temperature control, extracted them using a custom protocol, and analyzed with the ALZpath pTau217 Simoa assay.
  • Utilized CSF biomarkers for Aβ-positive classification and performed cognitive assessments (MMSE, CDR-Global), analyzing data with correlation, linear models, and ROC curve analysis.

Main Results:

  • Capillary DPS pTau217 strongly correlated with venous plasma pTau217 (rs=0.74) and mirrored associations with cognitive scores and age.
  • Capillary DPS pTau217 showed a discriminative accuracy of 0.863 for AD pathology, with a 198% elevation in affected individuals.
  • Strong correlations were observed for NfL (rs=0.83) and GFAP (rs=0.773) between capillary DPS and venous plasma.

Conclusions:

  • Detecting and quantifying AD biomarkers from capillary blood using DPS is feasible and accurate.
  • This simple, temperature-independent method can facilitate the identification of individuals at high risk for AD.
  • The approach broadens access to biomarker testing, particularly in research settings.