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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Juliana de Oliveira Alves1

  • 1Universidade Feevale, Novo Hamburgo, Rio Grande do Sul, Brazil.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Novel digital tools show promise for early Alzheimer's disease (AD) detection. These rapid, sensitive assessments, including the Digital Clock and Recall (DCR) test and smartphone-based TapTalk, offer accessible dementia screening, especially in primary care.

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Area of Science:

  • Neurology
  • Gerontology
  • Biomarker Research

Background:

  • Alzheimer's disease (AD) and other dementias represent a growing global health challenge with increasing prevalence.
  • Early detection, particularly in the preclinical stage, is critical for effective intervention to slow disease progression.
  • Traditional cognitive tests like the Mini-Mental State Examination (MMSE) have limitations in sensitivity, speed, and susceptibility to demographic factors, highlighting the need for improved dementia screening tools.

Purpose of the Study:

  • To evaluate novel digital assessment tools and biomarkers for the early and accurate detection of Alzheimer's disease (AD).
  • To compare the efficacy of new screening methods against traditional cognitive assessments.
  • To explore the potential of accessible, rapid tools for dementia screening in primary care settings.

Main Methods:

  • A review of three studies published within the last five years from the Medline database.
  • Evaluation of the Digital Clock and Recall (DCR) test against the MMSE for identifying mild cognitive impairment (MCI) and early dementia.
  • Investigation of smartphone-based TapTalk (combining speech/movement analysis with p-tau181 biomarkers) and the online TAS Test (integrating motor-cognitive functions with p-tau181) for preclinical AD risk assessment.

Main Results:

  • The DCR test demonstrated superior accuracy and sensitivity compared to the MMSE for MCI detection, with a shorter administration time and less demographic influence.
  • TapTalk identified preclinical AD risk through hand movement and speech patterns, indicating potential as a non-invasive tool.
  • The TAS Test successfully detected subtle motor changes preceding cognitive symptoms, proving useful for early AD stages.

Conclusions:

  • Digital assessments and biomarkers offer innovative, sensitive, and accessible methods for early AD detection.
  • These novel approaches have the potential to significantly improve dementia screening processes.
  • Widespread adoption in primary care could enable earlier interventions and better management of Alzheimer's disease.