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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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Drug Development.

Guy Gikelekele¹

¹CNPP/University of Kinshasa, Kinshasa, Kinshasa, Congo (The Democratic Republic of the).

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 25, 2025

Summary

This summary is machine-generated.

Neuropsychiatric symptoms like anxiety and sleep disturbance are linked to specific cognitive deficits in older adults with probable Alzheimer's disease (AD) in the DRC. This research highlights the need for integrated assessment of these symptoms and cognitive functions in AD diagnosis.

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Area of Science:

Neurology
Neuropsychology
Geriatrics

Background:

Limited research exists on neuropsychiatric symptoms (NPS) and cognitive function in dementia within Sub-Saharan Africa.
Alzheimer's disease (AD) research predominantly focuses on Western populations.

Purpose of the Study:

To investigate the association between NPS and cognitive functions in older adults with probable AD in Kinshasa, Democratic Republic of Congo (DRC).
To contribute to understanding AD manifestations in an underrepresented population.

Main Methods:

114 participants (56 probable AD, 58 normal cognition) matched for age, sex, and education in Kinshasa, DRC.
Assessed psychiatric symptoms using the Neuropsychiatric Inventory (NPI).
Evaluated cognitive functions with the African Neuropsychology Battery (ANB) and employed multiple linear regression for association analysis.

Main Results:

Anxiety showed a significant association with the proverb test (p=0.03).
Sleep disturbance was significantly linked to visuospatial memory (p=0.05).
A trend was observed between anxiety and visuospatial memory (p=0.06).

Conclusions:

Neuropsychiatric symptoms are integral to Alzheimer's disease manifestations and correlate with specific cognitive impairments.
The Neuropsychiatric Inventory (NPI) and African Neuropsychology Battery (ANB) are crucial tools for diagnosing probable AD, especially in diverse populations.