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Clinical Manifestations.

Angel Garcia De La Garza1, Carol A Derby1, Cuiling Wang1

  • 1Albert Einstein College of Medicine, Bronx, NY, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Daily pain is linked to increased subjective cognitive concerns in older adults. Managing pain may be crucial for maintaining cognitive health and daily functioning.

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Area of Science:

  • Gerontology
  • Cognitive Science
  • Pain Management

Background:

  • Pain is a common issue in older adults, often associated with cognitive problems.
  • The day-to-day impact of pain on subjective cognitive functioning is not well understood.
  • Smartphone-based ecological momentary assessments (EMA) can capture real-time data on pain and cognition, reducing recall bias.

Purpose of the Study:

  • To investigate the association between daily pain and subjective cognitive concerns (SCC) in community-dwelling older adults.
  • To understand how transient pain fluctuations influence cognitive self-perceptions and daily functioning.
  • To explore potential moderating factors in the pain-cognition relationship.

Main Methods:

  • Utilized EMA with 310 community-dwelling older adults over 14 days.
  • Assessed daily pain levels, pain interference with activities and concentration, and SCC.
  • Employed linear mixed-effects models to analyze associations, adjusting for covariates and exploring interactions.

Main Results:

  • Higher daily pain levels and pain interference were significantly associated with increased SCC.
  • Interactions were found between pain and gender/depression; females showed weaker associations, while higher depression amplified pain's effect on SCC.
  • No significant interactions were observed for cognitive status, age, or ethnicity.

Conclusions:

  • Daily pain experiences are associated with self-perceived cognitive functioning in older adults.
  • Pain management strategies are important for preserving cognitive health in this population.
  • EMA provides valuable insights into the dynamic relationship between pain and cognition.