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Updated: Jan 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

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Published on: December 11, 2016

Drug Development.

Juliana de Oliveira Alves¹, Marcelo Henrique Quaresma Castro Salomão²

¹Universidade Feevale, Novo Hamburgo, Rio Grande do Sul, Brazil.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 25, 2025

Summary

This summary is machine-generated.

Managing behavioral and psychological symptoms of dementia (BPSD) requires individualized pharmacological strategies. This analysis reviews medications for BPSD, emphasizing lowest effective doses and shortest durations to minimize risks.

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Area of Science:

Neurology
Psychiatry
Pharmacology

Background:

Dementia affects 47 million globally, with Behavioral and Psychological Symptoms of Dementia (BPSD) significantly impacting patient and caregiver quality of life.
BPSD encompass agitation, aggression, delusions, and hallucinations, necessitating effective management strategies.

Purpose of the Study:

To analyze and compare pharmacological management strategies for BPSD in dementia patients.
To provide an overview of medication options and their associated risks and benefits.

Main Methods:

A comparative analysis of three scientific articles from the Medline database.
Focus on pharmacological treatments for dementia-related behavioral symptoms.

Main Results:

Antipsychotics (typical and atypical) are common for agitation and psychosis, but carry risks like increased mortality and cerebrovascular events.
SSRIs, acetylcholinesterase inhibitors, memantine, analgesics, and anticonvulsants show varied efficacy and side effect profiles.
Haloperidol is for emergencies due to high side effect risk; risperidone, aripiprazole, and quetiapine offer alternatives with specific indications.

Conclusions:

Individualized pharmacological management is crucial, considering patient symptoms, comorbidities, and frailty.
Medications should be used at the lowest effective dose and for the shortest duration possible to mitigate adverse effects.