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Published on: September 20, 2018
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Clinical Manifestations.
Diego Bustamante-Paytan1, José Carlos Huilca2, Gregory Brown3
1Unidad de Investigación de Deterioro Cognitivo y Prevención de Demencia, Instituto Peruano de Neurociencias, Lima, Lima, Peru.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
Summary
Primary progressive aphasias (PPA) show overlapping symptoms, challenging diagnosis. This study found significant symptom overlap across semantic, nonfluent, and logopenic PPA variants, highlighting the need for refined diagnostic criteria.
Area of Science:
- Neurology
- Linguistics
- Neuroscience
Background:
- Primary progressive aphasias (PPA) involve progressive language decline.
- Current PPA variant classification (semantic, nonfluent, logopenic) faces diagnostic challenges due to overlapping symptoms.
Purpose of the Study:
- To analyze the presence and overlap of specific symptoms across different primary progressive aphasia variants.
- To evaluate diagnostic challenges in PPA variant identification.
Main Methods:
- A retrospective study of 22 PPA patients (50-80 years) diagnosed per Gorno-Tempini et al. (2011) criteria.
- Comprehensive neuropsychological assessment and MRI were used for diagnosis.
- Descriptive statistics compared symptom distribution among semantic (svPPA), nonfluent (nfvPPA), and logopenic (lvPPA) variants.
Main Results:
- High word-retrieval difficulties observed in 77.8% of svPPA and nfvPPA patients.
- Over half of logopenic PPA patients exhibited symptoms aligning with nonfluent PPA criteria.
- Bilingualism was common in nfvPPA; indigenous language speakers were rare across variants.
Conclusions:
- Significant symptom overlap exists among primary progressive aphasia variants.
- More accurate diagnostic criteria are needed, especially in linguistically diverse regions like Latin America.
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