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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Melody Li1,2, Lisa Soke2,3, Nupur Ghoshal3

  • 1Washington University School of Medicine in St. Louis, St. Louis, MO, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

The SUNBIRD study is evaluating blood biomarkers for Alzheimer's disease (AD) diagnosis in primary care. This research aims to improve early detection and treatment by assessing biomarker effectiveness and clinical utility.

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Area of Science:

  • Neurology
  • Biomarker Research
  • Clinical Diagnostics

Background:

  • Early Alzheimer's disease (AD) diagnosis is crucial for initiating anti-amyloid therapies.
  • Blood tests for AD diagnosis are available but lack testing in primary care settings.
  • Optimal use of biomarkers (amyloid-beta, phospho-tau, MTBR-tau) and influencing factors require further investigation.

Purpose of the Study:

  • To assess the impact of blood biomarkers on AD diagnosis and treatment in primary care.
  • To evaluate the prediction of clinical and cognitive decline using blood biomarkers.
  • To understand the influence of comorbidities, race, sex, and education on biomarker utility.

Main Methods:

  • The Study to Understand Novel Biomarkers in Researching Dementia (SUNBIRD) longitudinally follows ~2000 participants.
  • Participants are recruited from diverse community (SEABIRD) and primary care/neurology clinic cohorts.
  • Methods include research blood collection (amyloid, tau, neurofilament), cognitive assessments, surveys, and EHR data extraction.

Main Results:

  • Study enrollment is progressing well, with positive participant feedback on study acceptance.
  • The design, implementation, and enrollment of SEABIRD and SUNBIRD studies are being reviewed.
  • Outcomes of clinical testing and referrals will be presented.

Conclusions:

  • Real-world enrollment and engagement of primary care providers (PCPs) and neurologists in AD diagnosis are feasible.
  • Further research is needed to confirm the validity and clinical utility of blood biomarkers for AD diagnosis and treatment.