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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Shuhua Ren1, Yihui Guan2, Fang Xie3

  • 1Huashan Hospital, Shanghai, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary

Subjective cognitive decline (SCD) patients show distinct amyloid-beta (Aβ) deposition patterns and mild neurodegeneration. Brain Aβ levels correlate with executive function, while hippocampal volume relates to overall cognitive and language abilities, suggesting early Alzheimer's disease biomarkers.

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Area of Science:

  • Neuroscience
  • Radiology
  • Gerontology

Background:

  • Alzheimer's disease (AD) involves Aβ deposition, altered glucose metabolism, and gray matter volume (GMV) loss, particularly in the hippocampus and parahippocampal gyrus.
  • Subjective cognitive decline (SCD) represents an early stage of cognitive impairment potentially preceding AD.
  • Investigating these pathological hallmarks in SCD is crucial for early diagnosis and intervention.

Purpose of the Study:

  • To examine brain Aβ deposition, glucose metabolism, GMV, and neurodegeneration in individuals with SCD.
  • To explore the relationship between these neuroimaging markers and cognitive function in SCD patients.

Main Methods:

  • 144 participants (95 SCD, 49 controls) underwent neuropsychological tests, 18F-Florbetapir PET/CT, 18F-FDG PET/CT, and MRI.
  • Voxel-wise analyses identified differences in Aβ deposition, glucose metabolism, and GMV between SCD and control groups.
  • Correlation analyses assessed the association between neuroimaging findings and cognitive performance.

Main Results:

  • SCD patients exhibited higher Aβ deposition in the precuneus, posterior cingulate, and left frontoparietal lobe compared to controls.
  • Mild atrophy was noted in left occipital regions, with reduced glucose metabolism in the right parahippocampal gyrus.
  • Aβ deposition positively correlated with executive function, and hippocampal/parahippocampal volume correlated with overall cognitive, executive, and language functions.

Conclusions:

  • SCD patients display specific Aβ deposition patterns and mild neurodegeneration, primarily in the left hemisphere.
  • Neuroimaging markers like Aβ deposition and hippocampal volume show significant correlations with cognitive functions.
  • These findings highlight the potential of multimodal neuroimaging for identifying early AD biomarkers in SCD.