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Clinical Manifestations.

Loana De Los Santos1, Florentina Morello Garcia2, Carolina Agata Ardohain Cristalli1

  • 1Fleni, Buenos Aires, Buenos Aires, Argentina.

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Summary
This summary is machine-generated.

This study introduces a new roadmap with neuropsychological tools to help diagnose right temporal variant frontotemporal dementia (rtvFTD) in Spanish-speaking populations. It aids in differentiating rtvFTD from other dementias and personalizing treatments.

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Area of Science:

  • Neuroscience
  • Cognitive Neurology
  • Psychology

Background:

  • Right temporal variant frontotemporal dementia (rtvFTD) causes progressive atrophy in the right anterior temporal lobe (rATL), impairing social cognition and semantic-pragmatic understanding.
  • Latin America needs validated neuropsychological tools for rtvFTD assessment, as current diagnostic methods lack consensus and vary widely.
  • Challenges in rtvFTD diagnosis stem from terminology ambiguity and diverse assessment tools, necessitating standardized approaches.

Purpose of the Study:

  • To propose novel neuropsychological tools for characterizing rtvFTD's cognitive and social deficits.
  • To present a structured roadmap for differentiating rtvFTD from other dementia types.
  • To facilitate the design of personalized therapeutic interventions for rtvFTD patients.

Main Methods:

  • Studied two diagnosed rtvFTD cases at FLENI, Buenos Aires, Argentina.
  • Administered locally adapted neuropsychological tests focusing on semantic-pragmatic language and social cognition.
  • Correlated neuropsychological findings with MRI scans to validate the proposed diagnostic roadmap.

Main Results:

  • Patients showed significant deficits in naming, semantic fluency, pragmatic language, and emotion recognition, with preserved executive functions and memory.
  • Neuropsychological deficits correlated with rATL atrophy and hypometabolism, aligning with rtvFTD literature.
  • A regionally adapted cognitive battery was developed to capture rtvFTD symptoms and guide differential diagnosis.

Conclusions:

  • The proposed roadmap offers practical neuropsychological tests for rtvFTD assessment, especially in Spanish-speaking regions.
  • Integrating semantic-pragmatic and social cognition assessments enables precise differentiation of rtvFTD from other FTD variants.
  • This approach supports personalized therapeutic interventions, aiming to enhance patient quality of life and clinical practice.