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Clinical Manifestations.

Ta-Wei Guu1,2, Dag Aarsland3,4, Dominic H Ffytche5

  • 1Division of Psychiatry, Department of Internal Medicine, China Medical University Beigang Hospital, Yunlin, Taiwan.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Actigraphy, a wearable device, offers a more sensitive measure of sleep disturbances and irregularity in Alzheimer's disease patients compared to traditional questionnaires. This technology can complement existing methods and identify new therapeutic targets for agitation and sleep issues.

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Area of Science:

  • Gerontology
  • Neuroscience
  • Biomedical Engineering

Background:

  • Sleep disturbances and nocturnal behavioral and psychological symptoms of dementia (BPSD) are prevalent and challenging in Alzheimer's disease (AD) patients.
  • Current measurement methods rely on potentially imprecise carer-rated questionnaires.
  • This study investigates the utility of actigraphy and the GGIR R-package for objective sleep measurement in late-stage AD.

Purpose of the Study:

  • To evaluate the effectiveness of actigraphy in measuring sleep patterns in care home residents with late-stage Alzheimer's disease.
  • To compare actigraphy-derived sleep data with traditional questionnaire-based assessments (NPI-NH, PSQI).
  • To explore the correlation between sleep parameters and agitation symptoms.

Main Methods:

  • Utilized Geneactiv Original actigraphy devices and the GGIR R-package for sleep analysis in 28 participants from the STAND trial.
  • Assessed BPSD using caregiver-rated NPI-NH and PSQI at baseline, week 2, and week 4.
  • Employed Spearman correlation and linear regression to analyze device-based sleep variables against questionnaire data.

Main Results:

  • High prevalence of sleep problems was observed across all measurement tools.
  • Actigraphy revealed consistently low sleep regularity index and was more sensitive to time-dependent variables than questionnaires.
  • Moderate correlations were found between Wake-After-Sleep-Onset (WASO) duration and irritability.

Conclusions:

  • Nocturnal sleep is frequently poor and irregular in this AD population, with irregularity potentially missed by questionnaires.
  • Wearable actigraphy offers a valuable, objective measurement tool to complement existing methods in clinical trials.
  • Actigraphy data may provide insights for novel therapeutic targets for sleep disturbances and agitation in AD.