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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
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Clinical Manifestations
Angel Garcia De La Garza1, Carol A Derby1, Cuiling Wang1
1Albert Einstein College of Medicine, Bronx, NY, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
Summary
Daily stress, anxiety, and difficulty staying awake are linked to subjective cognitive concerns (SCC) in older adults. These daily experiences significantly impact self-perceived memory and cognitive difficulties.
Area of Science:
- Gerontology
- Cognitive Science
- Psychology
Background:
- Ecological momentary assessment (EMA) tracks subjective cognitive concerns (SCC) in real time.
- SCCs predict future cognitive decline, but their daily fluctuations are not well understood.
- Smartphone-based EMA can assess transient factors influencing SCCs in older adults.
Purpose of the Study:
- To investigate the influence of daily contextual factors on SCCs in community-dwelling older adults.
- To explore the real-time associations between daily experiences and self-perceived cognitive difficulties.
- To understand moment-to-moment relationships between daily life and SCCs.
Main Methods:
- 14-day smartphone-based EMA with 6 daily surveys.
- Assessed daily cognitive lapses, difficulty staying awake, stress, enjoyment, anxiety, and loneliness.
- Linear mixed-effects models analyzed associations, adjusting for demographics and cognitive status.
Main Results:
- 310 older adults participated, averaging 11.40 diary days.
- Difficulty staying awake, stress, loneliness, and anxiety were positively associated with SCCs.
- Difficulty staying awake and anxiety remained independently associated with SCCs in multivariable analysis.
Conclusions:
- Daily stress, emotions, and wakefulness are associated with subjective cognitive concerns.
- Contextual variables should be considered when using SCCs for cognitive impairment screening.
- Future research will explore individual vulnerabilities to contextual factors in predicting cognitive decline.
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