Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

489
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
489

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Intestinal Stroke Pathway: Redefining the Radiologist's Role in Mesenteric Ischemia.

AJR. American journal of roentgenology·2026
Same author

On the complementary role of perineal ultrasound in evaluating female pelvic organ prolapse.

Gynecology and pelvic medicine·2026
Same author

18F choline PET/MR to assess clinically significant disease in prostate cancer: correlation with maximum and total cancer core length obtained via template mapping biopsies.

Nuclear medicine communications·2026
Same author

Social Medicine Approaches to Community-Integrated Diabetes Care: A Narrative Review of Clinic-Based Triaging and Closed-Loop Referral Interventions.

Journal of general internal medicine·2026
Same author

Virtual monoenergetic imaging for metal artifact reduction in dental implant surgery using photon-counting detector computed tomography.

Imaging science in dentistry·2026
Same author

Health Care Utilization and Cancer Screening Among Patients with Neurodivergence in a Safety-Net Adult Primary Care Clinic.

Journal of general internal medicine·2026
Same journal

Iodinated Contrast Media Hypersensitivity in 115,966 Patients: Risk Factors, Severity Profiles, and the Impact of Iodine Concentration on Reaction Risk.

Investigative radiology·2026
Same journal

Improvement of Lung Nodule Volumetric Accuracy with Photon-counting Computed Tomography Over Energy-integrating Computed Tomography in Low-dose Screening: A Phantom Study.

Investigative radiology·2026
Same journal

Photon-counting CT in Anterior Cervical Discectomy and Fusion: Improved Metal Artifact Reduction and Impact on Bone Fusion Assessment.

Investigative radiology·2026
Same journal

Quantitative Synthetic MRI in Body Imaging: Technical Basis, Current Applications, and Future Directions.

Investigative radiology·2026
Same journal

Nonclinical Safety Assessment of Digadoglucitol, a Novel Magnetic Resonance Imaging Contrast Agent for the Central Nervous System.

Investigative radiology·2026
Same journal

Artificial Intelligence-Enhanced Identification of Incidental Findings in Prostate MRI.

Investigative radiology·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.6K

Liver Fat and Iron Quantification With Spectral Localizer Radiographs From Photon-counting Detector CT.

Andrin Tognella, Thomas Flohr, Johannes M Froehlich

    Investigative Radiology
    |December 26, 2025
    PubMed
    Summary
    This summary is machine-generated.

    Photon-counting detector CT (PCD-CT) spectral localizer radiographs accurately quantify liver fat content, even with iron deposition. This technique shows promise for opportunistic screening of hepatic steatosis and iron overload.

    Keywords:
    PCD-CTcomputed tomographyironliver fatlocalizer radiographnonalcoholic fatty liver diseasephoton-countingsteatosis

    More Related Videos

    Author Spotlight: A Non-Invasive Tool to Assess and Differentiate Fat Patterns in Liver Using 3D Dixon MRI
    05:37

    Author Spotlight: A Non-Invasive Tool to Assess and Differentiate Fat Patterns in Liver Using 3D Dixon MRI

    Published on: October 20, 2023

    2.1K
    Fat-Water Phantoms for Magnetic Resonance Imaging Validation: A Flexible and Scalable Protocol
    07:59

    Fat-Water Phantoms for Magnetic Resonance Imaging Validation: A Flexible and Scalable Protocol

    Published on: September 7, 2018

    12.0K

    Related Experiment Videos

    Last Updated: Jan 7, 2026

    Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
    08:41

    Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

    Published on: March 24, 2023

    1.6K
    Author Spotlight: A Non-Invasive Tool to Assess and Differentiate Fat Patterns in Liver Using 3D Dixon MRI
    05:37

    Author Spotlight: A Non-Invasive Tool to Assess and Differentiate Fat Patterns in Liver Using 3D Dixon MRI

    Published on: October 20, 2023

    2.1K
    Fat-Water Phantoms for Magnetic Resonance Imaging Validation: A Flexible and Scalable Protocol
    07:59

    Fat-Water Phantoms for Magnetic Resonance Imaging Validation: A Flexible and Scalable Protocol

    Published on: September 7, 2018

    12.0K

    Area of Science:

    • Medical Imaging
    • Radiology
    • Biomedical Engineering

    Background:

    • Quantifying liver fat content (LFC) using computed tomography (CT) is challenged by hepatic iron deposition and iodinated contrast agents.
    • Photon-counting detector CT (PCD-CT) offers spectral imaging capabilities that may overcome these limitations.

    Purpose of the Study:

    • To assess the feasibility and accuracy of quantifying LFC in the presence of iron using spectral localizer radiographs from PCD-CT.
    • To evaluate the impact of varying liver iron concentration (LIC) on LFC measurements.

    Main Methods:

    • Sixteen liver phantoms with controlled LFC (0-50%) and LIC (0-6 mg/mL) were scanned using PCD-CT spectral localizer radiography.
    • Material decomposition was performed to generate water and hydroxyapatite (HA) maps.
    • HA values were analyzed as a function of LFC and LIC across different tube current settings.

    Main Results:

    • Increasing LFC linearly decreased HA values, independent of LIC (r=0.997 to 1.0).
    • Increasing LIC linearly increased HA values, independent of LFC (r=0.978 to 1.0).
    • A 2D material space using water and HA values enabled LFC estimation irrespective of LIC, with reproducible findings across tube currents.

    Conclusions:

    • Spectral localizer radiographs from PCD-CT can accurately quantify liver fat content in the presence of hepatic iron deposition.
    • This technique holds potential for opportunistic, low-threshold screening for hepatic steatosis and iron overload using precontrast localizer scans.