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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Federica Cacciamani1,2, Graziella Mangin Laignel1, Audrey Gabelle3,4

  • 1Qairnel, Paris, France, France.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Informant-referred individuals with subjective cognitive decline show higher Alzheimer's disease risk profiles. This highlights the importance of informant reports for identifying those needing early intervention and support.

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Area of Science:

  • Gerontology
  • Neurology
  • Cognitive Science

Background:

  • Subjective cognitive decline (SCD) is a common concern in older adults, often reported by the individual or an informant.
  • Informant-reported SCD may indicate a higher risk for Alzheimer's disease and related disorders (ADRD).
  • DocMemo is a digital platform offering cognitive screening and resources for individuals with cognitive concerns and their informants.

Purpose of the Study:

  • To compare self-referred and informant-referred individuals on the DocMemo platform.
  • To investigate the association between referral type and established dementia risk factors.

Main Methods:

  • Users were categorized as self- or informant-referred based on a cognitive complaint questionnaire.
  • Multivariate logistic regression analyzed the association between referral type and various demographic, cognitive, psychological, health, and lifestyle factors.
  • Analyses were adjusted for multiple comparisons.

Main Results:

  • Informant-referred users (2,554) had higher cognitive complaints and were older than self-referred users (10,489).
  • Factors associated with informant referral included higher cognitive complaints, older age, and anxiety.
  • Factors associated with self-referral included being female, higher education, sleep disorders, smoking, and willingness to participate in research.

Conclusions:

  • Informant-referred users present with higher Alzheimer's disease risk profiles, consistent with modifiable dementia risk factors.
  • Informant reports are valuable for identifying individuals at higher risk, suggesting a vulnerable population.
  • Recognizing these differences is key for optimizing screening and providing timely support to at-risk individuals.