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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Melisa Gumus1, Luis Garcia Dominguez2, Wen Jia Zhao1

  • 1University of Toronto, Toronto, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Repetition suppression in the hippocampus shows age-related changes, with older adults exhibiting greater neural activation. This finding may help develop biomarkers for Alzheimer's Disease (AD).

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience

Background:

  • Alzheimer's Disease (AD) is associated with hippocampal hyperexcitability in early stages, shifting to hypoactivation as the disease progresses.
  • Repetition suppression, a measure of neural tuning during memory formation, is a potential biomarker for this neural shift.
  • Understanding age-related changes in hippocampal repetition suppression is crucial for biomarker development.

Purpose of the Study:

  • To investigate age-related differences in hippocampal repetition suppression using magnetoencephalography (MEG).
  • To identify distinct neural activation profiles in the hippocampus related to repetition suppression in young versus older adults.
  • To explore the potential of repetition suppression as a neural biomarker for AD.

Main Methods:

  • Magnetoencephalography (MEG) recordings were collected from 53 healthy young and older adults.
  • Participants viewed repeating scene images; repetition suppression was calculated as the oscillatory difference between novel and repeated presentations.
  • Hippocampal signals were localized using beamformer analyses, and time-frequency analyses characterized neural synchronies.

Main Results:

  • Healthy older adults showed significant hippocampal alpha and beta desynchronization for repeated images, indicating increased neural activity.
  • This desynchronization was less pronounced in healthy young adults.
  • Permutation testing confirmed significantly greater beta desynchronization in the hippocampus of older adults compared to younger adults.

Conclusions:

  • Hippocampal repetition suppression, a neural tuning mechanism, is altered by aging, showing greater activation in older adults.
  • Characterizing these age-related changes in repetition suppression is a promising approach for investigating hippocampal hyperexcitability as a potential AD biomarker.