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Clinical Manifestations.

Nadeshka J Ramirez-Perez1, Lusiana Martinez2, Randy Medrano2

  • 195 Grant Avenue, Medford, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
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The Latin American Spanish Preclinical Alzheimer's Cognitive Composite (LAS-PACC5) accurately assesses cognition in Spanish-speaking Latinos. This tool effectively identifies cognitive impairment, aiding early detection of Alzheimer's disease risk.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Psychometrics

Background:

  • Cognitive assessments in Spanish are crucial for evaluating Alzheimer's disease (AD) risk in Latino populations.
  • The Latin American Spanish Preclinical Alzheimer's Cognitive Composite (LAS-PACC5) was developed to detect early cognitive changes.
  • Existing cognitive measures were used to examine the LAS-PACC5's associations and diagnostic capabilities.

Purpose of the Study:

  • To validate the Latin American Spanish Preclinical Alzheimer's Cognitive Composite (LAS-PACC5) in a Latino population.
  • To assess the LAS-PACC5's correlation with existing cognitive measures.
  • To evaluate the LAS-PACC5's ability to differentiate between cognitively unimpaired and impaired individuals.

Main Methods:

  • 191 Spanish-speaking participants from the Boston Latino Aging Study (BLAST) were included.
  • The adapted LAS-PACC5, including the MMSE, FCSRT, and Category Fluency, was administered alongside other cognitive tests.
  • Statistical analyses included Mann-Whitney U tests and partial Spearman correlations, adjusting for age and education.

Main Results:

  • The LAS-PACC5 demonstrated positive correlations with memory and language measures (NEUROPSI Word List, semantic fluency, MINT).
  • The LAS-PACC5 significantly distinguished between unimpaired and impaired participants.
  • A large effect size was observed in differentiating between cognitive groups.

Conclusions:

  • The LAS-PACC5 exhibits convergent validity with memory and language assessments.
  • The LAS-PACC5 reliably detects cognitive impairment in Spanish-speaking older Latinos.
  • Future research should focus on longitudinal studies and AD-related biomarkers.