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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

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Biomarkers.

Simone P Zehntner1, Jean-Philippe Coutu1, Felix Carbonell1

  • 1Biospective Inc., Montreal, QC, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
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Summary
This summary is machine-generated.

Advanced MRI techniques precisely track Corticobasal Degeneration (CBD) progression and aid in differentiating it from other conditions. This imaging approach can accelerate clinical trials for rare neurodegenerative diseases.

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Area of Science:

  • Neuroimaging
  • Neurodegenerative Diseases
  • Biomarker Discovery

Background:

  • Corticobasal Degeneration (CBD) is a rare neurodegenerative disorder characterized by tau protein accumulation and neuronal loss.
  • CBD shares clinical similarities with other Parkinsonian syndromes, posing diagnostic challenges.
  • MRI biomarkers, including volumetric and diffusion MRI (dMRI), are crucial for monitoring disease progression and optimizing clinical trials.

Purpose of the Study:

  • To explore the progression of Corticobasal Degeneration (CBD) using advanced imaging techniques.
  • To differentiate CBD from similar neurodegenerative disorders, such as Progressive Supranuclear Palsy (PSP).
  • To assess the utility of advanced MRI in reducing sample size requirements for clinical trials.

Main Methods:

  • Utilized MRI data from CBD, PSP, and healthy control cohorts from the 4-Repeat Tauopathy Neuroimaging Initiative (4RTNI) and Frontotemporal Lobar Degeneration Neuroimaging Initiative (FTLDNI).
  • Employed the PIANO™ software platform for fully-automated volumetric and gray matter density assessments.
  • Analyzed diffusion MRI (dMRI) metrics, including radial diffusivity (RD) and free water (FW), to evaluate microstructural changes and calculated sample sizes for clinical trial efficacy.

Main Results:

  • CBD subjects exhibited accelerated brain atrophy, with significant gray matter density decreases in sensorimotor, parietal, and temporal cortices over 12 months.
  • Volumetric analysis showed 2.5%-5% regional reductions and subcortical atrophy in the thalamus and hippocampus.
  • Diffusion MRI revealed up to 5% changes in white matter and cortical diffusivity, with PIANO™ software significantly reducing required sample sizes compared to FreeSurfer.

Conclusions:

  • Advanced MRI, integrating volumetric and diffusion-based analyses, accurately tracks CBD progression and aids in differentiating it from PSP.
  • This methodology can potentially accelerate clinical trials by minimizing sample size requirements and facilitating early assessment of disease-modifying therapies.
  • Integrating robust imaging biomarkers is vital for enhancing diagnostic accuracy and therapeutic interventions in rare neurodegenerative diseases like CBD.