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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

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Published on: January 28, 2014

Biomarkers.

Simone P Zehntner¹, Jean-Philippe Coutu¹, Felix Carbonell¹

¹Biospective Inc., Montreal, QC, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 26, 2025

Summary

This summary is machine-generated.

Advanced MRI techniques significantly reduce the number of participants needed for Progressive Supranuclear Palsy (PSP) clinical trials by detecting subtle brain changes. This accelerates the development of new treatments for this rare neurodegenerative disease.

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Area of Science:

Neuroimaging
Neurodegenerative Diseases
Biomarker Discovery

Background:

Progressive Supranuclear Palsy (PSP) is a rare tauopathy causing movement and cognitive decline.
Abnormal tau accumulation leads to neuronal loss, particularly in the brainstem.
Identifying reliable biomarkers is crucial for efficient clinical trials in PSP.

Purpose of the Study:

To evaluate advanced MRI techniques for detecting PSP progression.
To assess the utility of volumetric and diffusion MRI (dMRI) in PSP.
To determine sample size reductions for PSP clinical trials using these methods.

Main Methods:

Utilized MRI data from PSP patients and controls (4RTNI, FTLDNI).
Employed fully-automated image processing with PIANO™ software.
Performed regional volumetric and dMRI analyses, including sample size calculations.

Main Results:

PSP patients showed significant volume loss (up to 4%) and microstructural changes over 12 months.
Advanced MRI methods required fewer than 50 participants per arm for trials.
These methods were more sensitive than FreeSurfer and MRPI, requiring smaller sample sizes.

Conclusions:

Integrated volumetric and dMRI analyses improve sensitivity to PSP brain changes.
Advanced MRI techniques significantly reduce sample size requirements for PSP trials.
Robust imaging biomarkers and analysis methods are key to efficient therapeutic development for PSP.