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Clinical Manifestations.

Yeshin Kim1, Hyemin Jang2, Jae-Won Jang1

  • 1College of Medicine, Kangwon National University, Chuncheon, Gangwon-do, Korea, Republic of (South).

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Engaging in more leisure activities may boost cognitive reserve (CR) in individuals with Early Onset Alzheimer

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Area of Science:

  • Neuroscience
  • Gerontology
  • Psychiatry

Background:

  • Cognitive Reserve (CR) explains the difference between brain damage and clinical symptoms.
  • Understanding CR is vital for dementia prevention strategies.
  • CR factors are understudied in Early Onset Alzheimer's Disease (EOAD), a rapidly progressing form.

Purpose of the Study:

  • To measure CR using brain age residuals (BAG) in EOAD patients.
  • To identify lifelong factors associated with CR in EOAD.

Main Methods:

  • Utilized data from the LEAF cohort (179 EOAD patients).
  • Quantified CR as Brain Age Gap (BAG) using a machine-learning brain age model from MRI T1 images.
  • Analyzed associations between lifelong factors (education, job, leisure, depression, stress) and BAG via multiple linear regression.

Main Results:

  • Mean participant age was 61.5 years; 69.2% were female.
  • Mean predicted brain age was 78.0 years, with a mean BAG of -20.0 years.
  • Higher levels of leisure activities showed a significant positive correlation with greater BAG (p=0.011).

Conclusions:

  • Leisure activities represent a potential modifiable factor influencing CR in EOAD.
  • Enhancing leisure activities may improve CR in EOAD patients.
  • Findings support dementia prevention strategies and future CR research in EOAD.