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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Yu-Yuan Huang1, Yu Guo2, Yi-Han Gan3

  • 1Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center, Fudan University, Shanghai, Shanghai, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Plasma p-tau217 significantly improves diagnostic confidence and leads to revisions in cognitive disorder diagnoses. This blood test is a less invasive, cost-effective alternative to PET and CSF examinations.

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Area of Science:

  • Neurology
  • Biomarker Research
  • Diagnostic Medicine

Background:

  • The clinical utility of plasma p-tau217 for diagnosing cognitive disorders is not well-established.
  • Current diagnostic methods like PET and CSF are invasive and costly.

Purpose of the Study:

  • To assess if plasma p-tau217 improves diagnostic accuracy and confidence in memory clinic patients.
  • To compare plasma p-tau217 performance against PET and CSF in diagnosing various cognitive conditions.

Main Methods:

  • 622 memory clinic patients underwent standard workup supplemented with plasma p-tau217 testing.
  • Diagnostic confidence and revisions were recorded post-p-tau217 analysis.
  • Performance metrics (sensitivity, specificity) were calculated against final diagnoses.

Main Results:

  • Plasma p-tau217 led to diagnostic revisions in 30.06% of cases and increased diagnostic confidence from 64.70% to 78.92%.
  • For Alzheimer's disease, plasma p-tau217 showed 0.88 sensitivity and 0.98 specificity, outperforming routine methods.
  • Performance was comparable to PET/CSF across cognitive stages and influenced diagnoses of frontotemporal dementia, vascular dementia, and synucleinopathies.

Conclusions:

  • Plasma p-tau217 significantly enhances diagnostic confidence and accuracy for cognitive impairment.
  • It serves as a less invasive, cost-effective, and accessible alternative to PET and CSF.
  • Integration into clinical practice can streamline diagnostics and optimize resources in memory clinics.