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Related Concept Videos

Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

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Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
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Endocarditis IV: Nursing Management01:29

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Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
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Related Experiment Video

Updated: Jan 7, 2026

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
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Enhanced Risk Stratification in Infective Endocarditis Surgery: A Comprehensive External Validation of All Available

Elisa Mikus1, Diego Sangiorgi1, Simone Calvi1

  • 1Cardiovascular Department, Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.

Clinical Epidemiology
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

The RISK-E score best predicts operative mortality in infective endocarditis (IE) surgery patients. This study validates IE-specific risk scores, finding RISK-E superior to generic models like EuroSCORE II.

Keywords:
external validationinfective endocarditismortalityrisk score

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Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Infective Endocarditis Research

Background:

  • Prognostic models for infective endocarditis (IE) surgery have uncertain external validity.
  • Existing models may not accurately predict operative mortality in diverse patient cohorts.

Purpose of the Study:

  • To externally validate and compare IE-specific and generic cardiac surgery risk scores.
  • To assess the performance of risk scores in a large single-center cohort of IE patients.

Main Methods:

  • Retrospectively applied 18 IE-specific and EuroSCORE II risk scores to 689 IE surgery patients.
  • Evaluated discrimination using AUC and calibration via Hosmer-Lemeshow, Brier score, and calibration slopes.
  • Assessed IE-specific variables' inclusion for score reliability.

Main Results:

  • Operative mortality was 10.6%. RISK-E score showed highest discrimination (AUC: 0.742), followed by APORTEI and modified MELD-XI.
  • All scores showed good calibration; IE-specific scores generally performed better.
  • Generic scores like EuroSCORE II overestimated risk; external validation yielded lower AUCs than original reports.

Conclusions:

  • The RISK-E score demonstrated superior discriminative ability and calibration for predicting operative mortality in IE surgery.
  • Externally validated, IE-specific prognostic tools are crucial for clinical assessment and perioperative strategy selection.