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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Ari Cuperfain1, Sara Pishdadian2, Janine Louis2

  • 1University of Toronto Temerty Faculty of Medicine, Toronto, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Excessive alcohol use (EAU) in older adults with mild cognitive impairment (MCI) increases memory intrusions, especially after interference. This suggests impaired cognitive control, impacting verbal memory recall.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Psychology

Background:

  • Excessive alcohol use (EAU) is linked to cognitive impairment in older adults.
  • Previous research indicated higher verbal memory intrusion rates in older adults with EAU.
  • This study further investigates alcohol's effects on verbal memory processes by analyzing intrusion types.

Purpose of the Study:

  • To characterize the impact of different levels of alcohol consumption on verbal memory recall in individuals with mild cognitive impairment (MCI).
  • To examine specific types of intrusions during verbal memory recall in relation to alcohol use.
  • To assess cognitive control differences in MCI patients based on alcohol consumption patterns.

Main Methods:

  • Utilized data from two multicenter cohorts (Comprehensive Assessment of Neurodegeneration and Dementia, Ontario Neurodegenerative Disease Research Initiative).
  • Included participants diagnosed with Alzheimer's disease MCI (AD-MCI) or cerebro-vascular disease MCI (V-MCI).
  • Categorized participants into 'zero', 'low-medium' (<1-7 drinks/week), or 'high' (>7 drinks/week) alcohol use groups and analyzed Rey Auditory Verbal Learning Test (RAVLT) intrusions, comparing changes between groups using independent t-tests.

Main Results:

  • Included 338 participants (mean age 71.6 years); 120 in zero, 153 in low-medium, and 65 in high alcohol groups.
  • No significant differences in total or specific intrusion types were found between groups initially.
  • The high alcohol group showed a significantly greater increase in intrusions after interference compared to zero (p=0.014) and low-medium (p=0.047) groups.

Conclusions:

  • Older adults with MCI and EAU demonstrate increased susceptibility to interference during recall, indicating impaired cognitive control.
  • Findings suggest that EAU negatively affects cognitive processes crucial for memory recall in MCI.
  • Results may guide future research on cognitive profiles and inform the development of cognitive training interventions for older adults with MCI and EAU.