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Clinical Manifestations.

Emrah Düzel1,2,3, Jochen René Thyrian4, Hannes Vossfeld5

  • 1German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
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This summary is machine-generated.

This study evaluates a digital tool for early Alzheimer's disease diagnosis. It aims to improve timely referrals for mild cognitive impairment (MCI) detection in specialized care settings.

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Area of Science:

  • Neurology
  • Digital Health
  • Geriatrics

Background:

  • Early diagnosis of mild cognitive impairment (MCI) in Alzheimer's disease (AD) is critical for intervention but challenging due to assessment complexity and time constraints.
  • Current German healthcare identifies less than 10% of MCI cases in primary care, necessitating validation of unsupervised digital remote assessment tools in routine care.

Purpose of the Study:

  • To investigate the potential of digital remote home-based assessment for improving efficient and timely referral of patients with suspected MCI.
  • To assess if remote digital self-assessment can enhance MCI referrals from specialized care to memory clinics.
  • To identify barriers to implementing digital tools for efficient MCI patient referral.

Main Methods:

  • The Refer-MCI study compares referral decisions using a remote digital self-assessment (neotivCare app) versus usual care.
  • Reference diagnosis of MCI due to AD will be made at memory clinics per S3 guidelines, with office-based MoCA assessment and blood-based AD biomarkers (pTau-217) also utilized.

Main Results:

  • The study will screen 500 patients (aged 60-80) with cognitive complaints across 27 offices, expecting 75% consent.
  • Specialists will document diagnoses and referral decisions before and after neotivCare use.
  • Patient enrollment is expected from May 2025 to February 2026.

Conclusions:

  • The Refer-MCI study aims to improve the efficiency and timeliness of MCI referrals using digital home-based assessments.
  • It will determine if remote digital self-assessment enriches memory clinic referrals with MCI patients.
  • The study will identify implementation barriers for these digital tools in specialized care.