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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Norman Scheel1,2, Jonathan M Reader2, Arijit K Bhaumik2

  • 1Michigan State University, East Lansing, MI, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Omega Entropy (Ω) measures brain activity complexity. Lower Ω in the Default Mode Network (DMN) and higher Ω in the limbic system correlate with better cognitive performance in older adults.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Medical Imaging

Background:

  • Resting-state functional MRI (rs-fMRI) is widely used to study brain connectivity.
  • Dimensional complexity measures, like Omega Entropy (Ω), analyze Eigenvalue (EV) spectrums to quantify rs-fMRI brain activity complexity.
  • Lower Ω indicates more coherent brain activity, while higher Ω suggests less coherence.

Purpose of the Study:

  • To investigate the association between Omega Entropy (Ω) and cognitive performance in an aging cohort.
  • To explore how brain activity complexity relates to cognitive function in older adults.

Main Methods:

  • Utilized rs-fMRI data from 132 participants (cognitively normal, mild cognitive impairment, Alzheimer's disease) from the Michigan Alzheimer's Disease Research Center.
  • Administered cognitive tests including the Montreal Cognitive Assessment (MoCA) and Hopkins Verbal Learning Test (HVLT).
  • Correlated cognitive scores with Ω measures of brain networks using Pearson correlations and Bonferroni correction.

Main Results:

  • HVLT total learning scores negatively correlated with Default Mode Network (DMN) Ω and positively with limbic system Ω.
  • HVLT delayed recall and MoCA total scores negatively correlated with DMN Ω.
  • Findings indicate associations between specific brain network Ω values and cognitive test outcomes.

Conclusions:

  • Higher cognitive performance (HVLT, MoCA) is linked to lower DMN Ω, suggesting more coherent activity.
  • Higher HVLT total recall scores are associated with higher limbic system Ω, indicating less coherent activity.
  • Ω shows potential as a biomarker for cognitive states in aging, particularly the limbic system's role warrants further investigation.