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Diuretic Response Prediction With MELD Score in Heart Failure.
Volkan Kozluca1, Irem Muge Akbulut1, Turkan Seda Tan1
1Ankara University Department of Cardiology, Ankara, Turkey.
Clinical Cardiology
|December 26, 2025
Summary
The MELD score derivative can help predict diuretic response in heart failure patients, potentially improving treatment strategies. This finding may aid in better managing heart failure phenotypes and outcomes.
Area of Science:
- Cardiology
- Nephrology
- Internal Medicine
Background:
- Heart failure (HF) presents significant global mortality challenges.
- Diverse HF phenotypes complicate treatment, with diuretic response (DR) varying significantly.
- Urinary parameters are emerging as tools for predicting DR.
Purpose of the Study:
- To investigate the utility of the Model for End-Stage Liver Disease (MELD) score as an additional predictor of diuretic response (DR) in patients with decompensated heart failure.
- To assess the association between MELD score derivatives and DR, particularly in relation to urinary sodium levels.
Main Methods:
- Eighty-one decompensated heart failure patients were analyzed.
- Second-hour urine sodium (UNa) and serum parameters were recorded post-diuretic administration.
- MELD score derivatives were evaluated for their predictive capability regarding DR.
Main Results:
- MELD Na score showed an independent association with DR (OR=0.88; p=0.008).
- MELD Na score was significantly correlated with urinary sodium levels (r=-0.354; p=0.004).
- Patients with poor DR (low UNa) required higher furosemide doses and had longer hospital stays.
Conclusions:
- The MELD score derivative, specifically MELD Na, is associated with diuretic response in heart failure patients.
- MELD score derivatives may serve as a valuable additional parameter for predicting DR.
- This finding could lead to more personalized and effective heart failure management strategies.
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