Related Experiment Video
Updated: Jan 7, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
Total Synthesis of Brasilicardin A
Zhe Wang1, Yuan Wang1, Danyang Hu1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Abstract:
This study reports a practical synthetic method for brasilicardin A, a diterpene natural product with potent immunosuppressive effects, possessing an unusual trans-syn-trans perhydrophenanthrene skeleton. The key reactions include a diastereoselective Eschenmoser-Claisen rearrangement, a highly diastereoselective alkylation of a decalin nitrile, and a Me2CuLi-mediated intramolecular Michael addition reaction to construct the strained, functionalized trans-syn-trans perhydrophenanthrene skeleton. In addition, an optimized protecting-group strategy was employed to reduce the need for subsequent deprotection steps and enhance reaction efficiency.
More Related Videos
08:56Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
05:59Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds
Published on: September 27, 2024
Related Concept Videos
Biosynthesis in Bacteria
β-Dicarbonyl Compounds via Crossed Claisen Condensations
Biosynthesis of Lipids
Benzene to 1,4-Cyclohexadiene: Birch Reduction Mechanism
Electrophilic Aromatic Substitution: Sulfonation of Benzene
Benzene to Phenol via Cumene: Hock Process