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Clinical Manifestations.

Tatiane Morgana da Silva1, Daniel Arnold2, Wyllians Vendramini Borelli2

  • 1Neurology Department, São Lucas Hospital of PUCRS, Porto Alegre, Rio Grande do Sul, Brazil.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Nearly half of behavioral variant frontotemporal dementia (bvFTD) patients use acetylcholinesterase (AchE) inhibitors or memantine. While these drugs may improve behavior, they also correlate with increased antidepressant use, necessitating further research.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Clinical Neurology

Background:

  • Frontotemporal dementia (FTD) treatment efficacy with acetylcholinesterase (AchE) inhibitors or memantine is debated.
  • Some studies show no benefit, while others indicate potential worsening of cognitive and behavioral symptoms in FTD patients.

Purpose of the Study:

  • To analyze the use and potential impact of AchE inhibitors and memantine in behavioral variant FTD (bvFTD) patients.
  • To compare demographic, cognitive, and behavioral characteristics of bvFTD patients with and without these medications.

Main Methods:

  • Analysis of National Alzheimer's Coordinating Center (NAAC) data (2005-2023) for bvFTD participants.
  • Comparison of medication use (AchE inhibitors, memantine, behavioral drugs) and cognitive/behavioral scores (CDR plus NAAC FTD).

Main Results:

  • Approximately 48% of 1,700 bvFTD participants used AchE inhibitors and/or memantine.
  • Patients on these medications were older and showed trends toward better scores in behavior, comportment, and personality.
  • This group also exhibited higher usage of antidepressants.

Conclusions:

  • Nearly 50% of bvFTD patients are treated with AchE inhibitors and/or memantine, despite limited evidence of efficacy.
  • These medications may positively influence behavior, comportment, and personality in bvFTD.
  • Increased antidepressant use in this cohort highlights the need for studies on effectiveness and safety.