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Related Concept Videos

Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
Introduction to Enzymes01:22

Introduction to Enzymes

The use of enzymes by humans dates to 7000 BCE. Humans first used enzymes to ferment sugars and produce alcohol without knowing that this was an enzyme-catalyzed reaction. Wilhelm Kuhne coined the term 'enzyme' in 1877 from the Greek words ‘en’ meaning ‘in’ or ‘within’ and ‘zyme’ meaning ‘yeast.’
Most enzymes are proteins that speed up biochemical reactions without being consumed. Enzymes contain one or more active sites that bind the substrates and convert them into products. Many enzymes also...

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Novel Bioactive Multifunctional Polyphenols: A Chemo-Enzymatic Approach.

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|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Researchers synthesized resveratrol derivatives to improve bioavailability for pharmaceutical and cosmetic applications. Some novel compounds demonstrated enhanced antioxidant and anti-inflammatory properties, surpassing resveratrol itself.

Keywords:
antioxidantsanti‐inflammatorygreen Chemistryhydrophilic/lipophilic Balancestilbene

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Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Biotechnology

Background:

  • Stilbenes, like resveratrol, offer valuable biological activities for pharmaceutical, nutraceutical, and cosmetic industries.
  • Low bioavailability of stilbenes limits their therapeutic and industrial applications.
  • Improving the hydrophilic/lipophilic balance (HLB) is crucial for enhancing stilbene bioavailability.

Purpose of the Study:

  • To synthesize novel alkyl glucoside dimers of resveratrol with optimized HLB values.
  • To evaluate the bioavailability, antioxidant, and anti-inflammatory potential of these synthesized compounds.
  • To explore their suitability for pharmaceutical, nutraceutical, and cosmetic applications.

Main Methods:

  • Synthesis of resveratrol derivatives (alkyl oxystilbenin diglucosides and δ-Viniferin diglucoside) via silver acetate-mediated oxidative coupling.
  • Functionalization of δ-Viniferin diglucoside using enzyme-mediated esterification with lauric acid.
  • Calculation of HLB values based on Log P, followed by antiradical (DPPH) and antioxidant (ORAC) assays, and anti-inflammatory testing on human dermal cells.

Main Results:

  • Nine alkyl glucoside dimers of resveratrol were synthesized.
  • Four synthesized compounds exhibited favorable HLB values for enhanced bioabsorption.
  • Antioxidant and anti-inflammatory assays indicated promising results, with some derivatives outperforming resveratrol.

Conclusions:

  • Novel resveratrol derivatives with improved bioavailability and potent biological activities were successfully synthesized.
  • The developed compounds hold significant potential for pharmaceutical, nutraceutical, and cosmetic applications.
  • This study provides a promising strategy for enhancing the efficacy of natural stilbenes.