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Clinical Manifestations.

Victória Tizeli Souza1, Barbara Loeblein Uebel2, Gabriela Raquel Paz Rivas3

  • 1Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

The Mild Behavioral Impairment Checklist (MBI-C) effectively identifies neuropsychiatric symptoms in individuals experiencing Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI). MBI-C scores correlate with anxiety, depression, and cognitive decline indicators, highlighting its clinical relevance.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Psychiatry

Background:

  • Mild Behavioral Impairment (MBI) involves neuropsychiatric symptoms that can precede neurodegenerative diseases.
  • Research on MBI in Brazilian individuals with cognitive complaints is limited.
  • This study evaluates the MBI-Checklist (MBI-C) in a Brazilian cohort with Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI).

Purpose of the Study:

  • To assess the utility of the MBI-Checklist (MBI-C) in identifying neuropsychiatric symptoms in individuals with SCD and MCI.
  • To explore the correlations between MBI-C scores and other measures of cognitive and psychological health.
  • To establish the relevance of MBI-C in behavioral assessments within the Brazilian population.

Main Methods:

  • The study analyzed data from the Brazilian Subjective Cognitive Decline (BRASCODE) cohort, including participants who completed a 12-month follow-up.
  • Participants underwent assessments including the MBI-Checklist (MBI-C), Memory Complaint Scale (MCS), Neuropsychiatric Inventory-Questionnaire (NPI-Q), Geriatric Depression Scale (GDS), Geriatric Anxiety Inventory (GAI), Mini-Mental State Examination (MMSE), and Clinical Dementia Rating (CDR).
  • Correlation analyses were performed to examine relationships between various clinical and demographic variables, with a significance level set at p < 0.05.

Main Results:

  • MBI-C participant scores positively correlated with depressive (GDS) and anxiety (GAI) symptoms.
  • MBI-C informant scores strongly correlated with the NPI-Q and informant-reported cognitive decline (CDR-SOB).
  • MBI-C participant scores showed a negative correlation with formal education; no significant correlation was found between participant and informant MBI-C scores.

Conclusions:

  • The MBI-C is effective in detecting neuropsychiatric symptoms in individuals with SCD and MCI.
  • MBI-C scores, particularly informant-based, show significant correlations with anxiety, depression, and cognitive impairment measures.
  • Further research with larger samples is recommended to fully understand MBI's association with cognitive decline in these populations.