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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
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Cardiac myocytes produce these hormones in response to ventricular stretching...
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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Faraz Honarvar1, Joshua Noronha2,3, Adam Gibicar3

  • 1Queen's University, School of Medicine, Kingston, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Intraplaque hemorrhage (IPH) is linked to white matter lesion (WML) asymmetry, suggesting it may be a marker for vascular disease and dementia risk. This finding could help identify high-risk patients for early intervention.

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Area of Science:

  • Neurology
  • Vascular Biology
  • Medical Imaging

Background:

  • Cerebrovascular disease (CVD) is a major cause of death and cognitive decline.
  • White matter lesions (WML) are early indicators of vascular damage and dementia.
  • Intraplaque hemorrhage (IPH) signifies carotid artery plaque instability.

Purpose of the Study:

  • To investigate the association between hemispheric WML asymmetry and IPH.
  • To identify novel biomarkers for vascular disease and dementia risk.
  • To explore the role of vascular factors in cognitive impairment.

Main Methods:

  • FLAIR MRI scans from 264 subjects were analyzed.
  • WML biomarkers (volume, intensity, ratio) and asymmetry index (AIM) were computed.
  • Linear mixed models and regression analyses assessed WML biomarkers and IPH status.

Main Results:

  • IPH-positive patients showed significant rightward WML asymmetry (volume, intensity, ratio).
  • Brighter lesions were more prevalent in the right hemisphere for IPH+ subjects.
  • IPH predicted WML asymmetry, especially with right carotid artery IPH.

Conclusions:

  • Rightward WML asymmetry is strongly associated with IPH.
  • This asymmetry may serve as a surrogate marker for vascular disease impacting brain health.
  • Automated WML biomarkers can identify high-risk individuals for early intervention.