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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Senal Peiris1, Qing Yang1, Anupa Manjitha Ekanayake Mudiyanselage1

  • 1Pennsylvania State University College of Medicine, Hershey, PA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Higher amyloid beta deposition, measured by PET scans, correlates with poorer cognitive function in individuals with mild cognitive impairment (MCI). This finding aids in streamlining Alzheimer

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Area of Science:

  • Neuroimaging
  • Neurology
  • Biomarkers

Background:

  • Alzheimer's disease (AD) diagnosis relies on anatomical changes seen in MRI, which can be ambiguous due to natural brain volume variations.
  • Amyloid imaging with Positron Emission Tomography (PET) offers a more accurate quantitative measure, Standardized Uptake Value Ratio (SUVr), for AD diagnosis.
  • Cognitive decline and olfactory impairment are early preclinical symptoms of AD, prompting investigation into brain-behavior relationships.

Purpose of the Study:

  • To explore the relationship between amyloid beta (Aβ) deposition, quantified by SUVr from PET scans, and cognitive and olfactory function in individuals with normal cognition (CN) and mild cognitive impairment (MCI).
  • To test the hypothesis that higher Aβ deposition (SUVr) is associated with poorer neuropsychological test scores.

Main Methods:

  • Amyloid beta (Aβ) PET scans were analyzed from 44 subjects (19 CN, 25 MCI).
  • Standardized Uptake Value Ratio (SUVr) was calculated using Clinica software after image pre-processing and registration to T1 MRI.
  • Correlation analyses between SUVr and behavioral test scores were performed using DPABI software.

Main Results:

  • Significant differences in neuropsychological scores and SUVr were observed between CN and MCI groups.
  • Correlation analyses revealed significant relationships between SUVr and various cognitive domains (p < 0.005).
  • The correlation between SUVr and olfactory function was not significant.

Conclusions:

  • Higher amyloid beta deposition is significantly linked to poorer cognitive performance in individuals with MCI.
  • Olfactory measures may require refinement for improved utility in assessing AD pathophysiology.
  • Findings suggest potential for streamlining neuropsychological test batteries for AD by focusing on metrics strongly correlated with amyloid beta deposition.