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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Cardiac myocytes produce these hormones in response to ventricular stretching...
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Irene Yang1, Kevin Hendler1, Frank A Scannapieco2

  • 1Emory University, Atlanta, GA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

This study investigates the link between periodontal disease and Alzheimer's disease risk. It explores how oral bacteria, inflammation, and social factors influence brain health and Alzheimer's biomarkers.

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Area of Science:

  • Neuroscience
  • Microbiology
  • Public Health

Background:

  • Periodontal disease (PerioD) is linked to Alzheimer's disease (AD) via inflammation.
  • Social determinants of health (SDoH) impact both oral health and AD risk but are understudied.
  • Neuroinflammation is a key feature of AD.

Purpose of the Study:

  • To compare the oral microbiome in individuals at high risk for AD with and without PerioD.
  • To investigate links between oral microbiome, SDoH, systemic/brain inflammation, and AD biomarkers.
  • To understand how SDoH influences PerioD and AD risk.

Main Methods:

  • Longitudinal study of 165 cognitively normal participants over two years.
  • Metagenomic sequencing of oral microbiome samples.
  • Collection of blood and cerebrospinal fluid (CSF) for inflammatory and AD biomarker analysis.
  • Surveys and interviews to assess behaviors and SDoH.

Main Results:

  • 55 participants recruited; average age 62, predominantly white (70%) and female (63.3%).
  • 85.7% have Stage 1-2 periodontitis.
  • Preliminary analysis shows no significant associations with small sample size, but future findings are anticipated.

Conclusions:

  • This research addresses gaps in understanding PerioD's role in AD risk.
  • It will provide insights into the interplay of oral microbiome, inflammation, and AD.
  • Explores upstream sociocultural factors influencing disease risk.