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Red Cell Distribution Width at 24 Hours as an Early Predictor of Mortality and Severity in Acute Pancreatitis: A
Alina Florentina Pistrițu1, Mihai Radu Pahomeanu2, Hosein Nayyerani3
1Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest; Internal Medicine and Gastroenterology Department, University Emergency Hospital of Bucharest, Bucharest, Romania. florentina-alina.pistritu@drd.umfcd.ro.
Background And Aims:
Acute pancreatitis (AP) presents with variable severity, and early identification of patients at risk for poor outcomes remains challenging. Red cell distribution width (RDW) is a widely available marker with potential prognostic value.
Methods:
We analyzed 682 patients from the RO-API/BUC-API registry admitted with AP between 2015 and 2023. RDW measured at 24±6 hours post-admission was assessed for associations with severity (per Revised Atlanta Classification) and in-hospital mortality. ROC analysis and logistic regression were applied.
Results:
Median RDW was significantly higher in non-survivors and patients with severe disease. RDW ≥13.85% predicted mortality [area under the curve (AUC)=0.67], and ≥14.35% predicted severe AP (AUC=0.67). RDW remained an independent predictor after adjusting for potential confounders.
Conclusions:
RDW at 24 hours could be a useful early biomarker for predicting severity and mortality in AP.
