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PERSISTENT DIFFUSE PHOTORECEPTOR DISORGANIZATION.

Miaoling Li1, Feng Wen, Lan Mi

  • 1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China .

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Summary
This summary is machine-generated.

Persistent diffuse photoreceptor disorganization (PDPD) causes subacute vision loss with distinct OCT findings. This condition, characterized by persistent photoreceptor disorganization, has a poor visual prognosis.

Keywords:
OCTellipsoid zoneinterdigitation zonephotoreceptor disorganization

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Medical Imaging

Background:

  • Persistent diffuse photoreceptor disorganization (PDPD) is a newly recognized retinal disorder.
  • Characterized by disruption of the ellipsoid zone and interdigitation zone on OCT.
  • Distinct from other outer retinopathies, it presents with subacute vision loss and largely unremarkable fundus examination.

Purpose of the Study:

  • To characterize persistent diffuse photoreceptor disorganization (PDPD).
  • To establish diagnostic criteria for PDPD.
  • To differentiate PDPD from similar outer retinal disorders.

Main Methods:

  • Retrospective observational case series of 14 patients (21 eyes) with subacute vision loss and persistent diffuse photoreceptor disorganization on OCT.
  • Multimodal imaging including OCT, fundus autofluorescence (FAF), fluorescein angiography (FA), and indocyanine green angiography (ICGA) was analyzed.
  • Visual function was assessed using electroretinography (ERG) and visual fields.

Main Results:

  • Patients presented with subacute vision loss (mean BCVA 0.9 LogMAR) and diffuse photoreceptor disorganization on OCT, including absent ellipsoid and interdigitation zones.
  • Outer retina thickness was significantly reduced in affected eyes (118.3 µm vs. 147.6 µm).
  • FA showed peripheral venous leakage in 75% of eyes; ERG revealed reduced amplitudes, and visual fields showed significant defects.

Conclusions:

  • PDPD is a distinct entity characterized by persistent photoreceptor disorganization with a generally poor visual prognosis.
  • Diagnostic criteria include subacute vision loss, unremarkable fundus, and specific OCT findings.
  • Further research into PDPD pathogenesis and treatment is warranted.