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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

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Biomarkers.

Wang Yuchuan¹, Helen J Mitchell¹, Susi Lee¹

¹Merck Sharp & Dohme LLC, West Point, PA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association

|December 26, 2025

Summary

This summary is machine-generated.

This study shows [¹¹C]MK-7337, a novel PET tracer, can successfully image alpha-synuclein (ASYN) pathology in Parkinson's disease (PD) patients. This breakthrough enables better diagnosis and tracking of Lewy-body disease progression.

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Area of Science:

Neuroimaging
Molecular Imaging
Radiochemistry

Background:

Clinical feasibility of imaging Lewy-body pathology in Parkinson's disease (PD) is unclear.
Alpha-synuclein (ASYN) is a key biomarker for PD and related Lewy-body disorders.
Development of novel PET radioligands is crucial for in vivo ASYN imaging.

Purpose of the Study:

To assess the clinical feasibility of imaging ASYN pathology in PD patients using a novel PET radioligand.
To evaluate the safety and performance of [¹¹C]MK-7337 in a first-in-human (FIH) study.
To compare ASYN tracer uptake in PD patients versus healthy elderly individuals.

Main Methods:

Radioligand binding assays were performed on postmortem brain tissues to determine affinity and selectivity.
In vivo PET imaging in mouse models and non-human primates (NHP) validated tracer performance and translational suitability.
A first-in-human (FIH) study involved PET imaging of eight PD patients and four healthy elderly (HE) participants using [¹¹C]MK-7337.

Main Results:

[¹¹C]MK-7337 demonstrated high affinity for ASYN pathology in vitro with suitable in vivo brain kinetics.
PET imaging in PD patients revealed elevated tracer uptake in brain regions associated with early ASYN pathology, including the midbrain and brainstem.
Similar tracer distribution and clearance patterns were observed between PD patients, HE participants, and preclinical NHP scans.

Conclusions:

[¹¹C]MK-7337 is a feasible PET radioligand for imaging alpha-synuclein pathology in Parkinson's disease.
This novel imaging approach holds potential for improved diagnosis and monitoring of PD.
Further research can leverage this tracer for understanding disease progression and therapeutic development.