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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Ambar Kulshreshtha1, Alvaro Alonso2, Yantong Kelly3

  • 1Emory University School of Medicine, Atlanta, GA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Carotid intima-media thickness (CIMT) is linked to white matter hyperintensity (WMH) volume, a marker of small vessel disease. This association is stronger in women and individuals under 60, suggesting vascular health impacts brain aging.

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Area of Science:

  • Neuroimaging
  • Vascular Biology
  • Gerontology

Background:

  • White matter hyperintensity (WMH) volume is a key indicator of small vessel disease and cognitive decline.
  • Carotid intima-media thickness (CIMT) measures early atherosclerosis and reflects vascular contributions to brain aging.

Purpose of the Study:

  • To investigate the association between CIMT and WMH volume in cognitively normal individuals.
  • To explore demographic differences in the CIMT-WMH relationship.

Main Methods:

  • Analysis of 872 participants from the Emory Healthy Brain Study.
  • Measurement of CIMT and quantification of WMH volume from MRI.
  • Linear mixed model analysis adjusted for covariates, with stratified analyses by age, race, and sex.

Main Results:

  • CIMT was significantly associated with WMH volume after adjusting for demographics and cardiovascular risk factors.
  • The association between CIMT and WMH volume was stronger in individuals under 60 and in women.
  • Age, hypertension, and diabetes were significant predictors of CIMT.

Conclusions:

  • An independent association exists between CIMT and WMH volume.
  • This relationship is more pronounced in younger individuals (<60) and women.
  • CIMT may indicate systemic vascular pathology affecting brain health and contributing to WMH.