Evaluation of the remineralization potential of bioactive materials using different methods
Ozlem Balkan1, Selcuk Savas1, Ebru Kucukyilmaz2
1Department of Pediatric Dentistry, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey.
Scientific Reports
|December 26, 2025
Summary
Bioactive restorative materials enhance enamel remineralization, significantly improving microhardness and reducing lesion areas. Fuji Triage demonstrated the highest remineralization capacity in this in vitro study.
Area of Science:
- Dental Materials Science
- Cariology
- Biomaterials
Background:
- Initial enamel caries represent a significant clinical challenge.
- Bioactive restorative materials offer potential for remineralization.
- Understanding their efficacy requires robust evaluation methods.
Purpose of the Study:
- To evaluate the remineralization capabilities of four bioactive restorative materials.
- To assess these materials on initial enamel lesions under in vitro conditions.
- To compare different evaluation methods for remineralization assessment.
Main Methods:
- In vitro study using 120 human molars with induced enamel lesions.
- Application of Fuji Triage, ACTIVA Bioactive Restorative, BeautiSealant, and Premier BioCoat.
- Evaluation using microhardness testing, SEM-EDS analysis, and quantitative light-induced fluorescence (QLF-D) over 3 months.
Main Results:
- All tested materials significantly increased enamel microhardness compared to demineralized areas.
- SEM-EDS analysis showed no significant elemental difference from sound enamel after 3 months.
- QLF-D analysis revealed significant reductions in lesion area and fluorescence for all materials.
- Fuji Triage exhibited the highest remineralization potential based on quantitative assessments.
Conclusions:
- Bioactive restorative materials promote enamel remineralization and lesion repair.
- These materials support minimally invasive caries treatment strategies.
- Fuji Triage shows promising results for enhancing tooth structure preservation.
