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Related Experiment Video

Updated: Jan 7, 2026

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Pulsatility Assessment of Cerebral Perforating Arteries Using Submillimeter-Resolution Dual-VENC Phase-Contrast MRI

Jianing Tang1,2, Sang Hun Chung1, Maria Gamez1

  • 1Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Journal of Magnetic Resonance Imaging : JMRI
|December 27, 2025
PubMed
Summary

Dual-velocity encoding (dual-VENC) phase-contrast MRI at 3T reliably assesses cerebral perforating artery pulsatility. This technique offers high-fidelity assessment and may be valuable for diagnosing cerebral small vessel disease.

Keywords:
arterial pulsatilitycerebral perforating arteriescerebral small vessel disease (cSVD)dual‐VENCphase‐contrast MRIpulsatility index (PI)

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Area of Science:

  • Neuroimaging
  • Vascular Biology
  • Medical Physics

Background:

  • Cerebral perforating artery dysfunction contributes significantly to cerebral small vessel disease.
  • Developing accessible MRI techniques for assessing these arteries is crucial.

Purpose of the Study:

  • To evaluate the feasibility and reliability of dual-velocity encoding (dual-VENC) phase-contrast MRI (PC-MRI) at 3T for assessing cerebral perforating artery pulsatility.

Main Methods:

  • A prospective study involving 12 healthy young adults and 31 older adults.
  • Dual-VENC 2D PC-MRI was performed at 3T and 7T.
  • Reproducibility and agreement between 3T and 7T were assessed, alongside associations with age, cognition, and vascular risk factors in older adults.

Main Results:

  • 3T dual-VENC PC-MRI demonstrated superior reproducibility for pulsatility index (PI) and number of perforators (Nperforator) compared to single VENC methods.
  • Measurements from 3T dual-VENC PC-MRI showed no significant difference compared to 7T dual-VENC.
  • Increased PI in older adults was associated with aging and cognitive impairment, but not Nperforator. Vascular risk factors were associated with PI, not Nperforator.

Conclusions:

  • 3T dual-VENC PC-MRI provides high-fidelity assessment of cerebral perforating artery pulsatility.
  • This technique is reliable and may serve as a valuable tool on widely accessible 3T MRI systems.