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Updated: Jan 7, 2026

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
Published on: May 21, 2020
Transcriptomic profiling of osteoblasts on hydroxyapatite-coated-metal-surface reveals enhanced osteogenic and
Yuki Ogawa1, Kosuke Arita1, Takayuki Nonoyama2
1Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, 060-8638, Japan.
Abstract:
Hydroxyapatite (HA) coating on orthopedic implants is known to promote osteogenesis and improve bone-implant integration, yet its molecular basis remains to be investigated. Here, transcriptomic profiling of osteoblasts on nano-HA (nHA)-coated surfaces revealed increased expression of key osteogenic and angiogenic molecules. These findings provide the first molecular mechanistic insight into how nHA coatings accelerate osteogenesis and bone healing.

